Howe: 'We need to perform'
But Eddie Howe knows his side will face a 'challenge' against the current Belgian Pro League leaders, who won 3-1 away at PSV in their first ever Champions League fixture two weeks ago.
Wednesday's game will be played at Anderlecht's Lotto Park, and Howe's side will train there on the eve of the match.
Before that, Howe addressed the media inside the bowels of the stadium and here are some of the main talking points from the United head coach's pre-match media briefing on Tuesday:
On Union Saint-Gilloise...
"They have started the season very strongly; they had a good result against PSV. Tactically, they are interesting, and they will give us a physical threat with two big strikers, we know it will be an important game on our Champions League journey but a tough one. This will be a good challenge for us at a time in the season where we need to perform."
On the team's journey to Brussels...
"Journey was good, quick flight for us, we will train this afternoon, the squad is in a good place, minus Tino [Livramento], still awaiting feedback on the extent of his injury but other than that we are okay. Fabian [Schär] is back in the squad."
On team-news...
"We will make a decision after training on how the players look physically; we will try and make the right decision in terms of team selection to make sure everyone is fresh."
On Nick Woltemade, who has scored twice in three starts for United...
"Great to see him score with his head, he is a big player, that has to be a source of goals for him, two headers so far, two outstanding moments, he’s made a positive start."
On training at Lotto Park...
"We felt coming here, getting to know our surroundings was very important. Getting to know the pitch and the stadium, get settled, and hopefully that will help our performance tomorrow."